Ranked by cost per milligram of active drug at a 10 mg maintenance dose, the cheapest tracked route to tirzepatide is Oak Longevity at $4.97 per milligram. The dearest tracked route costs $13.70 per milligram for the identical molecule — a spread of 2.8×.
Per-milligram pricing is the only comparison that survives the dose question. Monthly prices are not comparable between a patient at 2.5 mg and a patient at 15 mg, because one is buying four times the drug. Dividing by milligrams delivered removes the dose from the comparison entirely.
Why cost per milligram is the honest unit
A monthly tirzepatide price describes four weekly injections, and how much drug that represents depends entirely on the dose. At 2.5 mg weekly you receive 10 mg of active drug a month. At 10 mg weekly you receive 40 mg. At the 15 mg ceiling, 60 mg. A program charging the same monthly figure at all three is charging six times less per milligram at the top than at the bottom.
That is not an academic point. It is why a flat-rate program with a higher advertised price frequently beats a dose-scaled program with a lower one, and why the advertised figure — always quoted at the starter dose — is the least useful number in the market.
| Program | $/mg at 2.5 mg | $/mg at 10 mg | $/mg at 15 mg | 12-month total |
|---|---|---|---|---|
| Oak Longevity | $19.90 | $4.97 | $3.32 | $2,388 |
| NexLife | $21.50 | $5.38 | $3.58 | $2,580 |
| bmiMD | $23.30 | $5.83 | $3.88 | $2,796 |
| Join Fridays | $24.90 | $6.22 | $4.15 | $2,988 |
| Yucca Health | $25.80 | $6.45 | $4.30 | $3,096 |
| IVIM Health | $20.80 | $6.95 | $5.42 | $3,219 |
| Mochi Health | $27.80 | $6.95 | $4.63 | $3,336 |
| Direct Meds | $28.00 | $7.00 | $4.67 | $3,360 |
| ShedRx | $19.90 | $7.22 | $5.82 | $3,318 |
| SkinnyRx | $29.90 | $7.47 | $4.98 | $3,588 |
| MyStart Health | $29.90 | $7.47 | $4.98 | $3,588 |
| Gala Health | $29.90 | $7.47 | $4.98 | $3,588 |
| Sprout Health | $29.90 | $7.47 | $4.98 | $3,588 |
| Willow | $29.90 | $7.47 | $4.98 | $3,588 |
| Strut Health | $32.50 | $8.12 | $5.42 | $3,900 |
| Zealthy | $34.60 | $8.65 | $5.77 | $4,152 |
| TrimRx | $34.90 | $8.72 | $5.82 | $4,188 |
| OnlineSemaglutide.org | $34.90 | $8.72 | $5.82 | $4,188 |
| Found | $39.80 | $9.95 | $6.63 | $4,776 |
| MEDVi | $39.90 | $9.97 | $6.65 | $4,788 |
| Eden | $34.80 | $10.20 | $7.47 | $4,796 |
| LillyDirect (Zepbound) | $29.90 | $11.22 | $7.48 | $5,088 |
| LifeMD | $54.80 | $13.70 | $9.13 | $6,576 |
What the index says about the market
Three things. First, the spread is enormous for a commodity molecule: the cheapest and dearest tracked routes differ by a multiple, not a margin, and nothing about the medicine differs between them. Second, the ranking by monthly price and the ranking by unit price are not the same ranking, which is how programs advertise honestly and still mislead. Third, brand routes look far worse per milligram than they do per month, because their tiering is coarse.
How to use this index
Find the row for your expected maintenance dose, not your current one. If you are still titrating, the 10 mg column is the realistic planning figure, because that is where most patients spend most of the year. Then check the twelve-month column, because a unit price that looks good at one dose can still lose over a full course if the program reprices you on the way up.
What this index deliberately excludes
Service quality, shipping reliability, clinical depth and pharmacy disclosure. A cheap milligram from a program that will not name its pharmacy is not a good deal, and we score disclosure separately for exactly that reason. Use the index to shortlist, then run the verification checks before you pay anyone.
Tirzepatide Price Index: Cost Per Milligram, Ranked: the shortest useful summary
Tirzepatide is a once-weekly injection titrated from 2.5 mg to a 15 mg ceiling in 2.5 mg steps at intervals of at least four weeks, producing roughly 15 to 21% mean weight reduction across the studied maintenance arms at 72 weeks and about 20% against semaglutide's 14% in the only head-to-head trial. It works while it is taken; the withdrawal evidence shows substantial regain after stopping. Compounded preparations cost from $133 a month and are not FDA-approved; brand product is approved and costs considerably more.
Those five facts decide most questions people arrive with. Everything else on this page is detail underneath them — which is worth reading before you spend $2,388 on a first year, but not worth confusing with the outline.
Tirzepatide Price Index: Cost Per Milligram, Ranked: where to go next
If you have not chosen a program, price your expected maintenance dose with the projector rather than reading advertisements. If you have, check what it charges at 10 mg against the price-by-dose table. If you are struggling with side effects, the side-effect reference covers each one with reported frequencies and the red flags that need a clinician. And if a program has refused to name its pharmacy, the verification walkthrough explains why that single answer outranks any price difference.
People also ask about tirzepatide price index
What is tirzepatide price index?
Tirzepatide price index is covered in full on this page, with the clinical detail drawn from the tirzepatide prescribing information and the published SURMOUNT and SURPASS trial program, and any price figures drawn from our tracked dataset and dated to their last verification.
Does tirzepatide price index apply to compounded tirzepatide as well as Zepbound?
The molecule is the same, so the clinical content applies to both. What differs is regulatory status, dose metering and price: compounded preparations are not FDA-approved, arrive as a multi-dose vial you measure yourself, and cost a fraction of the brand routes.
How much does tirzepatide price index cost per month in 2026?
Compounded tirzepatide runs from $133 per month at the entry dose across the 21 compounded programs we track. At a 10 mg maintenance dose the cheapest tracked route is Oak Longevity at $199 per month, or about $2,388 for a first year on the standard escalation. Brand Zepbound through manufacturer self-pay sits well above that and pharmacy retail well above again. Verified 2026-08-05.
Is tirzepatide price index FDA-approved?
Brand tirzepatide (Zepbound and Mounjaro) is FDA-approved. Compounded tirzepatide is not: FDA does not approve compounded drugs and does not review them for safety, effectiveness or quality before they are marketed. The active molecule is the same; the regulatory review is not.
Sources
- US prescribing information for tirzepatide (Zepbound and Mounjaro), Eli Lilly and Company.
- SURMOUNT-1 — tirzepatide once weekly for the treatment of obesity, NCT04184622.
- SURMOUNT-5 — tirzepatide versus semaglutide in adults with obesity, NCT05822830.
- US Food and Drug Administration, human drug compounding — compounded drugs are not FDA-approved and are not reviewed by FDA for safety, effectiveness or quality before marketing.
- Program pricing as recorded in our open dataset, with a verification date on every record.